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Extra‐acral cutaneous sclerosing perineurioma with CD34 fingerprint pattern
Author(s) -
Macarenco Ricardo S.,
CuryMartins Jade
Publication year - 2017
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/cup.12882
Subject(s) - pathology , desmin , immunohistochemistry , cd34 , keratin , immunolabeling , s100 protein , biology , population , medicine , vimentin , microbiology and biotechnology , stem cell , environmental health
Sclerosing perineuroma is a variant of extraneural perineurioma that, as a rule, occurs in acral sites. However, it has also been occasionally reported in non‐acral regions. Recently, CD34 expression in a pattern reminiscent of the human fingerprint has been observed in a subset of perineuriomas, but this immunohistochemical finding has not been documented in non‐acral sclerosing perineuriomas. We report a case of sclerosing perineurioma presenting CD34 expression in a fingerprint‐like pattern on the skin of the neck (a previously unreported site for this neoplasm) of a 56‐year‐old man. In addition, alpha smooth‐muscle actin showed a similar pattern of expression, suggesting that the cell population implicated in the remarkable immunolabeling is most probably fibroblastic/myofibroblastic. Other immunohistochemical findings included epithelial membrane antigen and claudin1—positive lesional cells, and the absence of S100, glucose transporter protein 1, MUC4 and desmin.