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Primary dermal pleomorphic liposarcoma: utility of adipophilin and MDM2 / CDK4 immunostainings
Author(s) -
RamírezBellver Jose L.,
López Joaquín,
Macías Elena,
AlegríaLanda Victoria,
Gimeno Ignacio,
PérezPlaza Alejandra,
Kutzner Heinz,
Requena Luis
Publication year - 2017
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/cup.12850
Subject(s) - pathology , liposarcoma , immunostaining , immunohistochemistry , s100 protein , calponin , cd68 , biopsy , lipid droplet , perilipin , biology , medicine , adipose tissue , sarcoma , microbiology and biotechnology , endocrinology , lipolysis
Liposarcoma, usually arises in deep soft tissues and pleomorphic liposarcoma (PL), is the rarest histopathologic variant. However, 15 cases of entirely dermal PL have been reported. We describe a case of a 79‐year‐old man who developed a rapidly growing nodule on his thorax. Excisional biopsy was performed and immunohistochemical studies were carried. The lesion was a well‐circumscribed dermal nodule composed of multivacuolated pleomorphic lipoblasts and atypical mitotic figures. Neoplastic cells expressed CD10 and resulted negative S100 protein, Melan‐A, MITF ‐1, AE1 / AE3 , CD4 , CD68 ( PGM1 ), retinoblastoma gene family protein, pericentrine and lysozyme. Adipophilin stain showed the lipid contents in the cytoplasm of the neoplastic cells. MDM2 and CDK4 resulted both negative. A diagnosis of primary dermal PL was made. This case shows the utility of adipophilin immunostaining to prove the lipid contents in neoplastic cells, which has the advantage of using formalin‐fixed paraffin‐embedded tissue and making needless frozen sections and ultrastructural studies to show these findings. Negative MDM2 / CDK4 staining in our case argues against the possibility of dedifferentiated liposarcoma and further supports the diagnosis of true PL.