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The histopathologic features of autoimmune progesterone dermatitis
Author(s) -
James Travis,
Ghaferi Jessica,
LaFond Ann
Publication year - 2017
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/cup.12848
Subject(s) - medicine , pathology , eosinophilic , dermatology
Background The histologic features of autoimmune progesterone dermatitis (APD) are generally non‐specific and have been described only in brief case reports. We present a case of APD and review the literature with a focus on the histologic findings described. Methods A review of the English literature on APD was performed using PubMed and MEDLINE . Results A total of 39 patients, including our patient are included in this review. The most consistent histologic finding reported was a perivascular inflammatory infiltrate, being seen in 72% of cases. A non‐specific or interstitial inflammatory infiltrate was described in 31% of the cases, with 41% having an eosinophilic component and 21% having a neutrophilic component mixed with the predominant lymphocytic infiltrate. Interface dermatitis was the second most common finding with 36% showing a mild to exaggerated interface dermatitis. Conclusion Although histopathologic changes are non‐specific, perivascular dermatitis with eosinophils and interface changes are common in APD.