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Linear trichilemmomas on the ankle of a 28‐year‐old female
Author(s) -
Gonzalez Jessica L.,
Plotnikova Natalia,
Seymour Andrew,
Mannion Ciaran M.,
Danialan Richard,
Rosmarin David
Publication year - 2017
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/cup.12825
Subject(s) - pten , tensin , cowden syndrome , pathology , medicine , immunohistochemistry , germline , biopsy , biology , gene , apoptosis , biochemistry , pi3k/akt/mtor pathway
Trichilemmomas are benign cutaneous proliferations derived from the outer root sheath of the hair follicle. They most often occur on the head and neck region and show a female predominance. When multiple, they are associated with Cowden syndrome ( CS ), a rare disorder due to an autosomal dominant germline mutation in PTEN (phosphatase and tensin homolog on chromosome 10), a tumor suppressor gene. Trichilemmomas outside of the head and neck region are rare, and as such, the association with CS is not clear. A 28‐year‐old healthy female with no significant family history of cancer presented to her dermatologist with multiple erythematous papules on the left anterior ankle, starting at birth. A shave biopsy confirmed the diagnosis of trichilemmoma with focal desmoplastic features (or desmoplastic trichilemmoma). A PTEN immunohistochemical study showed patchy (but not complete) loss of staining of the lesional cells. After shave removal, the trichilemmomas recurred 1–2 months later.