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Cutaneous mantle cell lymphoma: a clinicopathologic review of 10 cases
Author(s) -
Gru Alejandro A.,
Hurley M. Yadira,
Salavaggione Andrea L.,
Brodell Lindsey,
Sheinbein David,
Anadkat Milan,
Porcu Pierluigi,
Frater John L.
Publication year - 2016
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/cup.12802
Subject(s) - blastoid , medicine , mantle cell lymphoma , pathology , lymphoma , trunk , stage (stratigraphy) , biology , ecology , paleontology
Cutaneous mantle cell lymphoma (MCL) is exceedingly rare, almost always occurring as a dissemination of systemic MCL. To date, only 32 cases have been described. We report a series of 10 cases of MCL in the skin, and provide a comprehensive clinicopathologic review with clinical follow‐up. Our cases occurred in older individuals (mean age = 70) and were more frequently in men (90%). Half of them presented in the head and neck region as a mass/nodule, and the remainder in the trunk and extremities as nodules. All patients have stage IV disease. In two of the 10 cases (20%) the cutaneous lesions preceded the diagnosis of disseminated disease. In two of the seven cases with available clinical follow‐up information (33%) the skin was immediately involved after the diagnosis of MCL, and in three of the seven the skin was the first site of recurrence (mean interval = 57 months). The mean time to recurrence of the disease was 45.4 months and the overall survival was 66.3 months. Histologically six out of 10 cases (60%) had either pleomorphic or blastoid morphology (four out of 10 and two out of 10, respectively). The mean number of mitoses per 10 high‐power fields was 18.44. While nine out of 10 cases expressed cyclin‐D1, one case was not positive for cyclin‐D1 but did label with SOX‐11. Limited cytogenetic data showed trisomy 14 in one case, in addition to the t(11;14) translocation.