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Skin manifestations of POEMS and AESOP syndrome in the same patient revealing plasma cell dyscrasia
Author(s) -
Rongioletti Franco,
Failla Maria C.,
Atzori Laura,
Ferreli Caterina
Publication year - 2016
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/cup.12798
Subject(s) - organomegaly , poems syndrome , plasma cell dyscrasia , dyscrasia , medicine , polyneuropathy , pathology , plasmacytoma , plasma cell , paraproteinemias , monoclonal gammopathy , dermatology , multiple myeloma , monoclonal , immunology , bone marrow , antibody , monoclonal antibody , immunoglobulin light chain
POEMS (polyneuropathy, organomegaly, endocrinopathy, monoclonal protein and skin signs) and AESOP (adenopathy and extensive skin patch overlying a plasmacytoma) syndromes are rare paraneoplastic conditions due to an underlying plasma cell dyscrasia. We report a 70‐year‐old patient with the rare coexistence of POEMS and AESOP syndromes and in whom skin signs, that differ both clinically and histologically, were the clues to the diagnosis of a plasma cell disorder. Vascular endothelial growth factor‐A overexpression seems to be the common pathogenetic link of the different clinicopathological presentations of the skin lesions.