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Histopathologic features of multiple cutaneous squamous cell carcinomas of the lower extremity
Author(s) -
Munday William R.,
Leffell David J.,
McNiff Jennifer M.,
Ko Christine J.
Publication year - 2016
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/cup.12738
Subject(s) - keratoacanthoma , perineural invasion , pathology , medicine , actinic keratosis , stage (stratigraphy) , clear cell , basal cell , skin cancer , metastasis , dermatopathology , carcinoma , cancer , dermatology , biology , paleontology
Recent studies suggest cutaneous squamous cell carcinomas (SCCs) of the leg, particularly those occurring multiply in sun exposed skin of nonimmunosuppressed women, are a distinct clinical subtype. There are few reports of the histopathologic features of this subtype. A retrospective chart review of 4 patients with multiple SCCs on the leg was performed and a total of 35 biopsies from the legs examined. Histopathologically, the tumors lacked adjacent actinic keratosis (AK) and often had adjacent basaloid retiform proliferations. Most lesions (all but one) were well differentiated and about 40% could be classified histopathologically as keratoacanthoma. Perineural invasion was absent in all but one case. Using the American Joint Committee on Cancer (AJCC) staging criteria for SCC, 21 tumors were Stage I, and 9 Stage II. During 7–10 years of follow‐up, no recurrence or metastasis occurred. Patients with multiple SCCs on the lower extremities can have a range of histopathologic features, from keratoacanthoma‐like to well‐differentiated SCC.