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Histopathologic and mutational analysis of a case of blue nevus‐like melanoma
Author(s) -
Dai Julia,
Tetzlaff Michael T.,
Schuchter Lynn M.,
Elder David E.,
Elenitsas Rosalie
Publication year - 2016
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/cup.12731
Subject(s) - melanoma , pathology , blue nevus , medicine , nevus , spitz nevus , dermatology , melanocytic nevus , dermatopathology , anatomical pathology , immunohistochemistry , cancer research
Blue nevi are a heterogeneous group of dermal melanocytic proliferations that share a common clinical appearance but remain controversial in their histopathologic and biologic distinction. While common blue nevi and cellular blue nevi are well‐defined entities that are classified without significant controversy, the distinction between atypical cellular blue nevi and blue nevus‐like melanoma remains diagnostically challenging. We report a case of a 46‐year‐old female with recurrent blue nevus‐like melanoma of the scalp with liver metastases; mutational analysis showed GNA11 Q209L and BAP1 Q393 mutations. To our knowledge, this is the first case of blue nevus‐like melanoma with GNA11 and BAP1 mutations. These particular mutations and the predilection for liver metastases in our patient's case underscore a fundamental biological relationship between blue nevi and uveal melanoma and suggest the two entities may prove amenable to similar diagnostic and prognostic testing and targeted therapies