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Histiocytoid neutrophilic dermatitis, an unusual histopathology in neonatal lupus erythematosus
Author(s) -
Sitthinamsuwan Panitta,
Nitiyarom Rattanavalai,
Chairatchaneeboon Manasmon,
Wisuthsarewong Wanee
Publication year - 2015
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/cup.12594
Subject(s) - histopathology , dermatopathology , medicine , pathology , dermatology , systemic lupus erythematosus , lupus erythematosus , disease , immunology , antibody
The authors reported histiocytoid neutrophilic dermatitis in neonatal lupus erythematosus ( NLE ). One‐month‐old male infant presented with annular erythematous plaques at the face and trunk. Serologic studies revealed positive anti‐ribonuclear protein antibodies ( RNP ) and antinuclear antibodies ( ANA ). Histopathology showed predominant myeloid lineage mononuclear cells admixed with segmented neutrophils. This finding is uncommon in cutaneous NLE . Cutaneous NLE and LE should be included in the differential diagnosis of histiocytoid neutrophilic dermatitis. Additional immunohistochemistry studies with clinical and serologic correlations are important to differentiate histiocytoid neutrophilic dermatitis from the other diagnoses, especially leukemic cutis in young patients.