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Granulomatous slack skin‐like clinical findings in Sézary syndrome
Author(s) -
Echeverria Begoña,
Vitiello Magalys,
Milikowski Clara,
Kerdel Francisco
Publication year - 2015
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/cup.12592
Subject(s) - mycosis fungoides , histopathology , pathology , histiocyte , giant cell , medicine , biopsy , dermatology , skin biopsy , lymphoma
Granulomatous slack skin ( GSS ) is a very rare condition that has been described as a variant of mycosis fungoides. It is characterized by the development of bulky and pendulous skin folds in flexural areas that are histologically formed by atypical T lymphocytes, histiocytes and giant cells. We report the case of a 37‐year‐old African‐American female with history of Sézary syndrome (SS) that while on treatment for the disease and in a space of 1 month developed exorbitant slack folds in the axillae and cervical area mimicking GSS . The absence of giant cells and epithelioid granulomas in the biopsy ruled out this diagnosis. We report this peculiar SS presentation that clinically resembles GSS , but with histopathology that does not show the typical features of this condition. We also review the literature in regard to SS , GSS and granulomatous mycosis fungoides ( GMF ), particularly the existing criteria to differentiate these various entities.