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Primary cutaneous CD8+ cytotoxic T‐cell lymphoma involving the epidermis and subcutis in a young child
Author(s) -
Wang Lei,
Gao Tianwen,
Wang Gang
Publication year - 2015
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/cup.12458
Subject(s) - lymphomatoid papulosis , cytotoxic t cell , medicine , pathology , cd30 , dermis , lymphoma , cd8 , t cell lymphoma , granzyme , panniculitis , granzyme b , mycosis fungoides , cutaneous t cell lymphoma , cutaneous lymphoma , perforin , biology , immunology , antigen , biochemistry , in vitro
CD8+ cytotoxic T‐cell lymphoma involving the skin represents a heterogeneous group of diseases that include subcutaneous panniculitis‐like T‐cell lymphoma, primary cutaneous aggressive epidermotropic CD8 + cytotoxic T‐cell lymphoma, and ‘type D’ lymphomatoid papulosis. In this report, we describe a case of CD8 + cytotoxic T‐cell lymphoma involving both the epidermis and subcutis. The patient was a 6‐year‐old girl who presented with a 3‐year history of multiple plaques on her trunk and legs. The lesions had relapsed twice but responded well to prednisone. Histopathologic examination showed the proliferation of atypical lymphocytes in the epidermis, dermis and subcutaneous tissue. On immunohistochemical analysis, the atypical lymphocytes were positive for βF1 , CD3 , CD8 , perforin, granzyme B and TIA ‐1, but negative for T‐cell receptor ( TCR ) γ, CD4 , CD30 and CD56 . It was difficult to classify this tumor in terms of the known types of cutaneous lymphoma, and this case should be differentiated with subcutaneous panniculitis‐like T‐cell lymphoma and primary cutaneous aggressive epidermotropic CD8 + T‐cell lymphoma.