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CD30 + clonal T‐cell lymphoid proliferation of the skin in a patient with hypereosinophilic syndrome
Author(s) -
Kempf Werner,
Kazakov Dmitry V.,
Szep Zoltan,
Vanecek Tomas
Publication year - 2015
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/cup.12454
Subject(s) - hypereosinophilic syndrome , hypereosinophilia , pdgfra , cd30 , clone (java method) , pathology , pdgfrb , skin biopsy , eosinophil , medicine , immunology , biology , lymphoma , biopsy , eosinophilia , dna , biochemistry , gist , stromal cell , asthma , gene , genetics
We report a hitherto undescribed unusual CD30 + clonal T‐cell proliferation in a 46‐year‐old man with the lymphocytic variant of hypereosinophilic syndrome with a 17‐year history of pruritus, generalized persistent papulonodular skin lesions and peripheral blood hypereosinophilia. A skin biopsy showed an eosinophil‐rich infiltrate with small to medium‐sized CD30 + lymphocytes and Churg‐Strauss granulomas. Peripheral blood flow cytometry revealed an aberrant T‐cell clone which, molecular genetically, was identical to the T‐cell clone detected in the skin. No genetic aberrations of platelet‐derived growth factor receptor alpha ( PDGFRA ), FIP1L1‐PDGFRA , PDGFRB or FGFR1 were found. The skin lesions showed transient response to systemic and topical corticosteroids. The skin lesions represent cutaneous involvement by clonal T‐cells in hypereosinophilic syndrome and differ from known cutaneous CD30+ lymphoproliferative disorders.