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Expression of WT ‐1 by the vascular component of acral pseudolymphomatous angiokeratoma of children
Author(s) -
FernandezFlores Angel,
Fierro Socorro,
Larralde Margarita
Publication year - 2015
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/cup.12429
Subject(s) - angiokeratoma , pseudolymphoma , pathology , medicine , lesion , papule , cd34 , blood vessel , lymphoma , biology , stem cell , genetics
Acral pseudolymphomatous angiokeratoma of children ( APACHE ) is a disease comprised by a dense dermal infiltrate of B‐lymphocytes and T‐lymphocytes in which prominent blood vessels with plump endothelium are found. In the past, the lesion was interpreted as a variant of angiokeratoma, a vascular malformation, or a nevus. Currently, most authors consider it to be a type of pseudolymphoma with prominent blood vessels. The latter express CD34 and D2 ‐40, while they lack the expression of Glut‐1. The expression of Wilms tumor‐1 ( WT ‐1) by APACHE has not yet been studied. In this report, we present a case of APACHE on the right foot of a 4‐year‐old boy and demonstrate immunoexpression of WT ‐1 by the blood vessels of the lesion. We also performed serial sections and demonstrated that the WT ‐1+ vessels with prominent endothelium were D2 ‐40−.