Expression of WT ‐1 by the vascular component of acral pseudolymphomatous angiokeratoma of children

Acral pseudolymphomatous angiokeratoma of children ( APACHE ) is a disease comprised by a dense dermal infiltrate of B‐lymphocytes and T‐lymphocytes in which prominent blood vessels with plump endothelium are found. In the past, the lesion was interpreted as a variant of angiokeratoma, a vascular malformation, or a nevus. Currently, most authors consider it to be a type of pseudolymphoma with prominent blood vessels. The latter express CD34 and D2 ‐40, while they lack the expression of Glut‐1. The expression of Wilms tumor‐1 ( WT ‐1) by APACHE has not yet been studied. In this report, we present a case of APACHE on the right foot of a 4‐year‐old boy and demonstrate immunoexpression of WT ‐1 by the blood vessels of the lesion. We also performed serial sections and demonstrated that the WT ‐1+ vessels with prominent endothelium were D2 ‐40−.