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Systemic amyloidosis presenting with glans penis involvement
Author(s) -
FernandezFlores Angel,
CastañónGonzález Jorge A.,
GuerreroRamos Brenda,
CastroGaytan Armando,
SaebLima Marcela
Publication year - 2014
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/cup.12378
Subject(s) - medicine , amyloidosis , glans penis , penis , al amyloidosis , dermatology , primary systemic amyloidosis , pathology , systemic disease , amyloid (mycology) , surgery , immunopathology , immunoglobulin light chain , immunology , antibody
Penile amyloidosis has been reported on many occasions in the literature, but all of these have been forms of primary cutaneous amyloidosis. Systemic amyloidosis presenting with a penile ulcer as the first manifestation has not previously been reported. We present two patients in whom an ulcer of the glans penis was the first complaint that led to a diagnosis of systemic amyloidosis. In both patients, lambda light chain type amyloid was showed immunohistochemically. Both patients presented with other manifestations of systemic amyloidosis, including nail dystrophy characterized by onycholisis, trachyonychia and onychoschizia.