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Expression of Prox1, D2 ‐40, and WT1 in spindle cell hemangioma
Author(s) -
Wang Lei,
Gao Tianwen,
Wang Gang
Publication year - 2014
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/cup.12309
Subject(s) - cd31 , pathology , hemangioma , immunohistochemistry , lymphatic system , biology , medicine , anatomy
Background Spindle cell hemangioma is a benign vascular proliferation that usually occurs on acral sites. A recent report showed focal positive staining of Prox1 in spindle cell hemangioma. Methods We performed an immunohistochemical study of spindle cell hemangioma with antibodies to CD31 , D2 ‐40, Prox1, smooth muscle actin ( SMA ) and Wilms tumor‐1 ( WT ‐1). Results The endothelial cells in spindle cell hemangioma were positive for CD31 and Prox1, focally positive for D2 ‐40 and negative for WT ‐1, whereas the myoid spindle cells around the endothelial cells were weakly positive for WT ‐1. Conclusion Our results suggest that spindle cell hemangioma is a lymphatic malformation.