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Multiple lesions of granular cell basal cell carcinoma: a case report
Author(s) -
Jedrych Jaroslaw,
Busam Klaus J.
Publication year - 2014
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/cup.12250
Subject(s) - pathology , granular cell tumor , basal cell carcinoma , eosinophilic , cd68 , immunohistochemistry , biopsy , medicine , granular cell , tongue , basal cell , central nervous system
Granular cell change in basal cell carcinoma ( BCC ) occurs rarely. Only 11 such cases have been reported; all of them were solitary nodular BCC . We report herein a case of multiple granular cell BCC with infundibulocystic features. The tumors presented as papules on the anterior neck of a 44‐year‐old female with a prior history of a well‐differentiated squamous cell carcinoma ( SCC ) of the tongue and radiation involving the area in which BCC developed. Microscopically, the tumors were circumscribed small dermal nodules composed of epithelial cords with granular eosinophilic cytoplasm and entrapped infundibular keratocysts. Given the eosinophilic appearance of the tumor, history of SCC and the lesions multiplicity, the initial biopsy was first interpreted as metastatic SCC . The correct diagnosis of granular cell BCC was established upon rereview of the slides at a cancer center. Given the diagnostic controversy, immunohistochemical stains were performed. The tumor cells expressed Ber‐ EP4 , CD63 ( NKI / C3 ) and CD68 . The tumors were compared to the prior SCC finding different morphologies. Extensive clinical evaluation showed no evidence of recurrent SCC . This report expands the clinicopathologic spectrum of granular cell variant of BCC and documents for the first time eruption of multiple such tumors in a localized area.