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Panfollicular carcinoma or trichoblastic carcinoma with panfollicular differentiation?
Author(s) -
Fedeles Flavia,
Cha Jisun,
Chaump Michael,
Theroux Brian,
Farrell David,
Dufresne Raymond,
RobinsonBostom Leslie
Publication year - 2013
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/cup.12219
Subject(s) - pathology , neoplasm , immunohistochemistry , malignancy , carcinoma , staining , biology , medicine
Herein, we report two cases of a follicular neoplasm with panfollicular differentiation showing architectural and cytologic findings suggestive of a malignancy. Immunohistochemical analysis of β‐catenin expression in the neoplasm showed nuclear and cytoplasmic immunoreactivity, with no reactivity in the transitional and shadow cells, consistent with β‐catenin expression of pilomatrical tumors. Staining for BerEp4 was positive at the periphery of both neoplasms, suggesting germinative differentiation of the neoplastic cells, whereas staining for the follicular stem‐cell marker PHLDA ‐1 ( TDAG51 ) showed strong focal expression in the tumor cells of both cases. Given these findings, these neoplasms show features of both panfollicular neoplasms and basal cell carcinoma with panfollicular/matrical differentiation. These are the first cases of this neoplasm reported to date. More reports are needed to assess their malignant potential.