Premium
Hard palate hyperpigmentation secondary to chronic chloroquine therapy: report of five cases
Author(s) -
de Andrade Bruno Augusto Benevenuto,
Fonseca Felipe Paiva,
Pires Fábio Ramôa,
Mesquita Ana Terezinha Marques,
Falci Saulo Gabriel Moreira,
dos Santos Silva Alan Roger,
Vargas Pablo Agustin,
Jorge Jacks,
de Almeida Oslei Paes
Publication year - 2013
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/cup.12182
Subject(s) - hyperpigmentation , medicine , chloroquine , dermatology , hard palate , pathology , dentistry , malaria
Antimalarials are commonly prescribed in medical practice for conditions such as rheumatoid arthritis, lupus erythematosus, as well as malaria. They are generally well‐tolerated, but side effects, although infrequent, are well known. The antimalarial chloroquine diphosphate may be associated with a bluish‐gray to black hyperpigmentation of the oral mucosa, mainly on the hard palate. In this report we described five additional cases of palate hyperpigmentation related to the chronic use of chloroquine diphosphate. Professionals must be aware of the adverse effects of antimalarials as chloroquine diphosphate in order to make the correct diagnosis and appropriate management of the patient. Early diagnosis of oral pigmentation by antimalarials may be of great relevance, because it might be an early sign of ocular involvement, and therefore it may be helpful to prevent further complications of antimalarial therapy for the patient.