Premium
Cutaneous presentation of chronic lymphocytic leukemia as unique extramedullar involvement in a patient with normal peripheral blood lymphocyte count (monoclonal B‐cell lymphocytosis)
Author(s) -
Tapia Gustavo,
Mate JoséLuis,
Fuente MaríaJosé,
Navarro JoséTomás,
FernándezFigueras MariaTeresa,
Juncà Jordi,
Ferrándiz Carlos,
Ariza Aurelio
Publication year - 2013
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/cup.12167
Subject(s) - lymphocytosis , medicine , chronic lymphocytic leukemia , pathology , organomegaly , immunophenotyping , monoclonal , lymphocyte , bone marrow , population , leukemia , atypical lymphocyte , biopsy , dermatopathology , skin biopsy , immunology , flow cytometry , monoclonal antibody , lymphoma , polyneuropathy , antibody , environmental health
Skin infiltration by chronic lymphocytic leukemia ( CLL ) is very rare and almost all reported cases occur in advanced stage. We report a patient with no relevant past medical history who presented with cutaneous erythematous plaques. A punch biopsy showed typical CLL morphologic and immunophenotypic features. Subsequent studies revealed a normal lymphocyte count in peripheral blood, and there was no evidence of lymphadenopathy or organomegaly. Flow cytometry demonstrated a clonal B‐cell population both in the bone marrow and peripheral blood (1.60 × 10 9 /l) with a CLL phenotype, but it did not fulfill required criteria for CLL diagnosis. Without cutaneous involvement, this case should be classified as monoclonal B‐cell lymphocytosis.