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Expression of CK7 , C am 5.2 and Ber‐Ep4 in cutaneous squamous cell carcinoma
Author(s) -
Clarke Loren E.,
Conway Andrea B.,
Warner Nicole M.,
Barnwell Patricia N.,
Sceppa Jennifer,
Helm Klaus F.
Publication year - 2013
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/cup.12135
Subject(s) - pagetoid , cytokeratin , immunohistochemistry , medicine , basal cell , pathology , extramammary paget's disease , disease
Background Cytokeratin 7 ( CK 7) and Cam 5.2 are often used to differentiate extramammary Paget's disease ( EPD ) from squamous cell carcinoma ( SCC ) in situ because they are generally considered to be expressed in the former but not in the latter. However, we have encountered CK7 + and Cam 5.2+ SCCs . Methods We evaluated CK7 , Cam 5.2 and Ber‐Ep4 expression in SCC and EPD . Results We found significant CK7 and Cam 5.2 positivity in SCCs , particularly in those with a pagetoid pattern. Only one case expressed Ber‐Ep4. Conclusions We conclude that CK7 and Cam 5.2 expression may occur in SCC . A panel including Ber‐Ep4 is advisable for immunohistochemical differentiation of EPD from SCC .
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