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Indolent course of cutaneous gamma‐delta T‐cell lymphoma
Author(s) -
Endly Dawnielle C.,
Weenig Roger H.,
Peters Margot S.,
Viswanatha David S.,
Comfere Nneka I.
Publication year - 2013
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/cup.12091
Subject(s) - medicine , malignancy , lymphoma , pathology , disease , cutaneous t cell lymphoma , cutaneous lymphoma , dermatology , mycosis fungoides
Cutaneous gamma‐delta T‐cell lymphoma (γδ TCL ) is a rare malignancy that typically displays an aggressive clinical course. We present an unusual case of a 57‐year‐old woman with a 3‐year history of lower extremity nodules. Histopathologic, immunophenotypic and molecular genetic studies revealed a clonal, predominantly pannicular gamma‐delta T‐cell infiltrate, leading to a diagnosis of cutaneous γδ TCL . The clinical course was characterized by rapid improvement within months of starting systemic corticosteroids, with relapse in ulcerations but no new lesions more than 3 years after onset of disease. Our case and seven previously reported patients with indolent and relatively localized cutaneous γδ TCL provide evidence that not all cases of this entity carry a poor prognosis. This indolent subset adds complexity to treatment of cutaneous γδ TCL .