Open AccessDeveloping Pharmacogenomic Reports: Insights from Patients and Clinicians
Author(s) -
Jones Laney K.,
Kulchak Rahm Alanna,
Gionfriddo Michael R.,
Williams Janet L.,
Fan Audrey L.,
Pulk Rebecca A.,
Wright Eric A.,
Williams Marc S.
Publication year - 2018
Publication title -
clinical and translational science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.303
H-Index - 44
eISSN - 1752-8062
pISSN - 1752-8054
DOI - 10.1111/cts.12534
Subject(s) - pharmacogenomics , workflow , variety (cybernetics) , medicine , stakeholder , medline , bioinformatics , computer science , pharmacology , biology , biochemistry , public relations , database , artificial intelligence , political science
Increasingly, for a variety of indications, patients have their genomes sequenced and actionable results returned. A subset of returned results is pharmacogenomic (PGx) variants involved in the metabolism or action of medications. Although the impact of these variants on health is well‐documented, little research exists on how to communicate these findings to patients and clinicians. We conducted semistructured interviews with end users to understand how best to communicate PGx results. Overall, patients and clinicians had similar opinions regarding report content, delivery, and application. Unique concerns specific to each stakeholder group were also expressed. Patients wanted an easy‐to‐understand individualized report that clinicians utilized to guide their care. Clinicians wanted reports that were easy‐to‐use, actionable, and integrated into their workflow. Implementation of these reports in a clinical setting will allow for broader user feedback and iterative improvement.