Open AccessThe Clinical Translation Gap in Child Health Exercise Research: A Call for Disruptive Innovation
Author(s) -
Ashish Naveen,
Bamman Marcas M.,
Cerny Frank J.,
Cooper Dan M.,
D'Hemecourt Pierre,
Eisenmann Joey C.,
Ericson Dawn,
Fahey John,
Falk Bareket,
Gabriel Davera,
Kahn Michael G.,
Kemper Han C.G.,
Leu SzuYun,
Liem Robert I.,
McMurray Robert,
Nixon Patricia A.,
Olin J. Tod,
Pianosi Paolo T.,
Purucker Mary,
RadomAizik Shlomit,
Taylor Amy
Publication year - 2015
Publication title -
clinical and translational science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.303
H-Index - 44
eISSN - 1752-8062
pISSN - 1752-8054
DOI - 10.1111/cts.12194
Subject(s) - translational medicine , translational research , medicine , health care , clinical trial , disease , child health , medline , translational science , alternative medicine , knowledge translation , medical education , family medicine , pathology , knowledge management , computer science , political science , law , economics , economic growth
Abstract In children, levels of play, physical activity, and fitness are key indicators of health and disease and closely tied to optimal growth and development. Cardiopulmonary exercise testing (CPET) provides clinicians with biomarkers of disease and effectiveness of therapy, and researchers with novel insights into fundamental biological mechanisms reflecting an integrated physiological response that is hidden when the child is at rest. Yet the growth of clinical trials utilizing CPET in pediatrics remains stunted despite the current emphasis on preventative medicine and the growing recognition that therapies used in children should be clinically tested in children. There exists a translational gap between basic discovery and clinical application in this essential component of child health. To address this gap, the NIH provided funding through the Clinical and Translational Science Award (CTSA) program to convene a panel of experts. This report summarizes our major findings and outlines next steps necessary to enhance child health exercise medicine translational research. We present specific plans to bolster data interoperability, improve child health CPET reference values, stimulate formal training in exercise medicine for child health care professionals, and outline innovative approaches through which exercise medicine can become more accessible and advance therapeutics across the broad spectrum of child health.