Open AccessRate of Change of Carotid Intima‐Media Thickness with Magnesium Administration in Abcc6 −/− Mice
Author(s) -
Kupetsky Erine A.,
Rincon Fred,
Uitto Jouni
Publication year - 2013
Publication title -
clinical and translational science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.303
H-Index - 44
eISSN - 1752-8062
pISSN - 1752-8054
DOI - 10.1111/cts.12057
Subject(s) - medicine , pseudoxanthoma elasticum , intima media thickness , endocrinology , carotid arteries , stroke (engine) , pathology , mechanical engineering , engineering
Abstract Pseudoxanthoma elasticum (PXE), caused by mutations in the ABCC6 gene, demonstrates progressive build‐up of calcium phosphate and proteoglycans in the skin, eye, and arteries, and is associated to myocardial infarctions, stroke, blindness, and elevated carotid intima‐media thickness (CIMT). Although CIMT reduction with magnesium (Mg) has been documented in a mouse model for PXE (Abcc6 −/− ), it is not clear if Mg is effective in humans with PXE to reduce CIMT. To examine this, we calculated the rate of change of CIMT (washout) in 15‐ and 12‐month‐old Abcc6 −/− mice fed standard rodent diet with or without Mg supplementation for 2 months. Using means in untreated 15‐ and 12‐month‐old Abcc6 −/− mice (145 and 120 μm, respectively), the rate of change was 8.3 μm/month. Using means in treated 15‐ and 12‐month‐old Abcc6 −/− mice (118 and 104.6 μm, respectively), the rate of change was 4.5 μm. Compared to normal progression of CIMT in humans without PXE, PXE has advanced atherosclerosis and possibly a higher CIMT rate of change. This experiment may portend, at least in PXE, the rationale for a 1‐year oral Mg CIMT clinical trial and may be useful for application in other progressive mineralizing disorders like atherosclerosis.