Open AccessClinical Significance of Vimentin Expression and Her‐2 Status in Patients with Gastric Carcinoma
Author(s) -
Zhao Wenwen,
Yue Lu,
Zhou Fang,
Xu Congcong,
Liang Wanhua,
Sui Aihua,
Ding Aiping,
Qiu Wensheng
Publication year - 2013
Publication title -
clinical and translational science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.303
H-Index - 44
eISSN - 1752-8062
pISSN - 1752-8054
DOI - 10.1111/cts.12043
Subject(s) - vimentin , immunohistochemistry , pathology , medicine , metastasis , stage (stratigraphy) , cancer , adenocarcinoma , carcinoma , oncology , clinical significance , biology , paleontology
Objectives To determine whether vimentin could be used as a marker of gastric carcinomas with more aggressive behavior. To detect the extent of Her‐2 status in gastric carcinoma and explore the correlation between vimentin expression and Her‐2 status. Methods Vimentin expression was detected in surgically resected gastric carcinoma tissue specimens from 143 patients by immunohistochemistry. The human epidermal growth factor receptor 2 (Her2) status was evaluated by fluorescence in situ hybridization (FISH). Correlations between vimentin expression, Her‐2 status and clinicopathological factors were evaluated using Kaplan‐Meier method and Cox multivariate survival models. Results Vimentin expression was significantly correlated with age, advanced stage, poorly differentiated type, venous invasion, hepatic metastasis, and recurrence ( p < 0.05). Her‐2 gene was amplified in 16 (11.2%) out of the 143 gastric carcinoma tissue specimens. Her‐2 status was correlated with advanced cancer, poor differentiation, venous invasion, hepatic metastasis, and recurrence ( p < 0.05). The result of multivariate analysis showed that vimentin expression and lymph node metastasis were independent prognostic factors. Conclusions Vimentin expression in epithelial cells of the surgically resected gastric adenocarcinoma tissue is an independent predictor of short survival, and Her‐2 status shows a valuable correlation with clinical parameters.