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Cardiac transplantation in adult congenital heart disease with prior sternotomy
Author(s) -
Kainuma Atsushi,
Ning Yuming,
Kurlansky Paul A.,
Axsom Kelly,
Farr Maryjane,
Sayer Gabriel,
Uriel Nir,
Lewis Matthew J.,
Rosenbaum Marlon S.,
Kalfa David,
LaPar Damien J.,
Bacha Emile A.,
Takayama Hiroo,
Naka Yoshifumi,
Takeda Koji
Publication year - 2021
Publication title -
clinical transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 76
eISSN - 1399-0012
pISSN - 0902-0063
DOI - 10.1111/ctr.14229
Subject(s) - medicine , heart transplantation , intracardiac injection , heart disease , perioperative , transplantation , surgery , cardiology , dialysis
Background Adult congenital heart disease (ACHD) patients who require orthotopic heart transplantation are surgically complex due to anatomical abnormalities and multiple prior surgeries. In this study, we investigated these patients’ outcomes using our institutional database. Methods ACHD patients who had prior intracardiac repair and subsequent heart transplant were included (2008–2018). Adult patients without ACHD were extracted as a control. A comparison of patients with functional single ventricular (SV) and biventricular (BV) hearts was performed. Results There were 9 SV and 24 BV patients. The SV group had higher central venous pressure/pulmonary capillary wedge pressure ( P = .028), hemoglobin concentration ( P = .010), alkaline phosphatase ( P = .022), and were more likely to have liver congestion ( P = .006). Major complications included infection in 16 (48.5%), temporary dialysis in 12 (36.4%), and graft dysfunction requiring perioperative mechanical support in 7 (21.2%). Overall in‐hospital mortality was 15.2%. Kaplan‐Meier analysis showed a higher, but not statistically significant, survival after 10 years between the ACHD and control groups (ACHD 84.9% vs. control 67.5%, P = .429). There was no significant difference in 10‐year survival between SV and BV groups (78% vs. 88%, P = .467). Conclusions Complex ACHD cardiac transplant recipients have a high incidence of early morbidities after transplantation. However, long‐term outcomes were acceptable.