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Sleeve gastrectomy enables simultaneous pancreas and kidney transplantation in severely obese recipients
Author(s) -
Rössler Fabian,
Hübel Kerstin,
Di Natale Samuela,
Oberkofler Christian,
Gerber Philipp,
Bueter Marco,
de Rougemont Olivier
Publication year - 2021
Publication title -
clinical transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 76
eISSN - 1399-0012
pISSN - 0902-0063
DOI - 10.1111/ctr.14197
Subject(s) - medicine , surgery , transplantation , body mass index , pancreas , diabetes mellitus , kidney transplantation , dialysis , pancreas transplantation , concomitant , sleeve gastrectomy , urology , weight loss , obesity , endocrinology , gastric bypass
Abstract Background Obesity adversely affects wait‐listing and precludes patients with concomitant end‐stage renal disease and type 1 diabetes mellitus from getting a simultaneous pancreas and kidney transplantation (SPK). Objective To analyze safety and efficacy of laparoscopic sleeve gastrectomy (LSG) before SPK in severely obese type I diabetics. Methods We assessed weight curve, complications, and graft function of three patients who underwent LSG before SPK. Results LSG was uneventful in all patients. Body mass index dropped from 38.4 (range 35.7 ‐ 39.9) before LSG to 28.5 (26.8 ‐ 30.9) until SPK, with a mean loss of 25.8% (22.4 ‐ 32.3). Interval between LSG and SPK was 364.3 (173 ‐ 587) days. Pancreas and kidney graft function was excellent, with 100% insulin‐free and dialysis‐free survival over a mean follow‐up of 3.6 (2.9 ‐ 4.5) years. A1C dropped from 7% (6.3 ‐ 8.2) before LSG to 4.9% (4.7 ‐ 5.3) and 4.8% (4.5 ‐ 5.1) 1 and 2 years after SPK, respectively. Conclusion LSG before SPK is safe and effective to enable severely obese type I diabetics to receive a lifesaving transplant. This is the first study analyzing the role of bariatric surgery before simultaneous pancreas and kidney transplantation.