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Impact of PNPLA3 (rs738409‐G) polymorphism on post‐transplant outcomes after liver transplantation for alcohol‐related liver disease
Author(s) -
Yoo Tae,
Lee KwangWoong,
Yi NamJoon,
Hong Suk Kyun,
Lee JeongMoo,
Kim Hyeyoung,
Lim Jieun,
Seo Sooin,
Suh KyungSuk
Publication year - 2020
Publication title -
clinical transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 76
eISSN - 1399-0012
pISSN - 0902-0063
DOI - 10.1111/ctr.14011
Subject(s) - medicine , liver transplantation , gastroenterology , alcoholic liver disease , odds ratio , genotype , liver disease , transplantation , single nucleotide polymorphism , allele , genotyping , cirrhosis , genetics , biology , gene
We aimed to evaluate the association between PNPLA3 polymorphism and post‐liver transplantation (LT) outcomes related to alcohol relapse (AR). Method We retrospectively analyzed data from patients receiving LT for alcoholic liver disease (ALD) from 04/2014 to 12/2017. Liver‐related clinical outcomes were assessed by the gamma‐glutamyltransferase (GGT) level and alcohol‐related liver failure (ARLF). Genotyping was performed using prospectively collected DNA samples in both donors and recipients. Results A total of 83 recipients were enrolled. Post‐LT AR occurred in 31 patients (37.3%). Thirty‐one patients (14 AR, 9 abstainers) showed elevated GGT levels, and 3 AR patients experienced ARLF. In the multivariate analysis, rs738409 G allele carrier and heavy drinking (HRAR score ≥ 4) were independent risk factors for elevated GGT levels (odds ratio [OR] = 8.69, P < .01; OR = 13.07, P = .01) and ARLF (OR = 4.52, P = .04; OR = 19.62, P = .03). Among 15 heavy AR patients, being an rs738409 G allele carrier was related to GGT elevation ( P = .03) and ARLF ( P = .04), but it was not related to GGT elevation in mild drinkers (n = 16) or abstainers (n = 52). Conclusion PNPLA3 polymorphism of the recipient genotype can independently affect the post‐LT prognosis of LT patients for ALD, especially in heavy AR patients. Therefore, strong abstinence education is recommended in patients with this single nucleotide polymorphism.