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Strict selection criteria in uncontrolled donation after circulatory death provide excellent long‐term kidney graft survival
Author(s) -
Miñambres Eduardo,
Rodrigo Emilio,
Suberviola Borja,
Valero Rosalía,
Quintana Alfredo,
Campos Félix,
RuizSan Millán Juan Carlos,
Ballesteros María Á.
Publication year - 2020
Publication title -
clinical transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 76
eISSN - 1399-0012
pISSN - 0902-0063
DOI - 10.1111/ctr.14010
Subject(s) - medicine , machine perfusion , kidney transplantation , kidney , renal function , urology , circulatory system , surgery , perfusion , transplantation , donation , liver transplantation , economics , economic growth
Background We aimed to report our experience in uncontrolled donation after circulatory death (uDCD) kidney transplantation applying a strict donor selection and preservation criteria. Methods All kidney recipients received a graft from a local uDCD. As controls, we included all renal transplants from local standard criteria donation after brain death (SDBD) donors. Normothermic regional perfusion was the preservation method in all cases. Results A total of 19 kidneys from uDCD donors were included and 67 controls. Delayed graft function (DGF) was higher in the uDCD group (42.1% vs 17.9%; P = .033), whereas no differences were observed in primary nonfunction (0% cases vs 3% controls; P = .605). The estimated glomerular filtration rate was identical in both groups. No differences were observed in graft survival censored for death between the uDCD and the SDBD groups at 1‐year (100% vs 95%) or 5‐year follow‐up (92% vs 91%). uDCD kidney recipients did not have higher risk of graft loss in the multivariate analysis adjusted by recipient age, cold ischemic time, presence of DGF, and second kidney transplant (HR: 0.4; 95% CI 0.02‐6; P = .509). Conclusions Obtaining renal grafts from uDCD is feasible in a small city and provides similar outcomes compared to standard DBD donors.