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Prescription patterns of opioids and non‐steroidal anti‐inflammatory drugs in the first year after living kidney donation: An analysis of U.S. Registry and Pharmacy fill records
Author(s) -
Vest Luke S.,
Sarabu Nagaraju,
Koraishy Farrukh M.,
Nguyen MinhTri,
Park Meyeon,
Lam Ngan N.,
Schnitzler Mark A.,
Axelrod David,
Hsu Chi Yuan,
Garg Amit X.,
Segev Dorry L.,
Massie Allan B.,
Hess Gregory P.,
Kasiske Bertram L.,
Lentine Krista L.
Publication year - 2020
Publication title -
clinical transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 76
eISSN - 1399-0012
pISSN - 0902-0063
DOI - 10.1111/ctr.14000
Subject(s) - medicine , medical prescription , pharmacy , opioid , incidence (geometry) , odds ratio , family medicine , pharmacology , physics , receptor , optics
We examined a novel database linking national donor registry identifiers to records from a US pharmaceutical claims warehouse (2007‐2015) to describe opioid and NSAID prescription patterns among LKDs during the first year postdonation, divided into three periods: 0‐14 days, 15‐182 days, and 183‐365 days. Associations of opioid and NSAID prescription fills with baseline factors were examined by logistic regression (adjusted odds ratio, LCL aOR UCL ). Among 23,565 donors, opioid prescriptions were highest during days 0‐14 (36.6%), but 12.6% of donors filled opioids during days 183‐365. NSAID prescriptions rose from 0.5% during days 0‐14 to 3.3% during days 183‐365. Women filled opioids more commonly than men, and black donors filled both opioids and NSAIDs more commonly than white donors. After covariate adjustment, significant correlates of opioid prescription fills during days 183‐365 included obesity (aOR, 1.24 1.38 1.53 ), less than college education (aOR, 1.19 1.31 1.43 ), smoking (aOR, 1.33 1.45 1.58 ), and nephrectomy complications (aOR, 1.11 1.29 1.49 ). NSAID prescription fills in year 1 were not associated with differences in estimated glomerular filtration rate, incidence of proteinuria or new‐onset hypertension at the first and second year postdonation. Prescription fills for opioids and NSAIDs for LKDs varied with demographic and clinic traits. Future work should examine longer‐term outcome implications to help inform safe analgesic regimen choices after donation.