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Long‐term outcome of percutaneous transhepatic biliary drainage for biliary strictures following pediatric liver transplantation
Author(s) -
Sanada Yukihiro,
Katano Takumi,
Hirata Yuta,
Yamada Naoya,
Okada Noriki,
Onishi Yasuharu,
Yasuda Yoshikazu,
Mizuta Koichi
Publication year - 2019
Publication title -
clinical transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 76
eISSN - 1399-0012
pISSN - 0902-0063
DOI - 10.1111/ctr.13570
Subject(s) - medicine , liver transplantation , biliary drainage , percutaneous , transplantation , biliary tract , gastroenterology , surgery
Background We present a retrospective analysis of our experience with pediatric liver transplantation (LT), focusing on the long‐term outcome of percutaneous transhepatic biliary drainage (PTBD) for post‐transplant biliary strictures. Methods Fifty‐three PTBDs were performed for 41 pediatric recipients with biliary strictures. The median ages at LT and PTBD were 1.4 and 4.4 years, respectively. The median observation period was 10.6 years. Results Post‐transplant biliary strictures comprised anastomotic stricture (AS) in 28 cases, nonanastomotic stricture (NAS) in 12, anastomotic obstruction (AO) in 8, and nonanastomotic obstruction (NAO) in 5. The success rate of PTBD was 90.6%, and the 15‐year primary patency rate of PTBD was 52.6%. The recurrence rate of biliary strictures after PTBD was 18.8% (9/48), and among the four NAS cases with recurrence, two underwent re‐LT. The biliary obstruction rate was 27.1% (13/48). Among the eight cases with AO, five underwent the rendezvous method and three underwent surgical re‐anastomosis. Among the five cases with NAO, one underwent re‐LT. The recipient survival rate of PTBD treatment was 100%. Conclusions The graft prognosis of AS by PTBD treatment is good and AO is curable by the rendezvous method and surgical re‐anastomosis. However, the graft prognosis of NAS and NAO is poor.