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Lung cancer after lung transplantation: An analysis of 25 years of experience in a single institution
Author(s) -
Chatron Eva,
Dégot Tristan,
Salvaterra Elena,
Dumazet Antoine,
Porzio Michele,
Hirschi Sandrine,
Schuller Armelle,
Massard Gilbert,
RenaudPicard Benjamin,
Kessler Romain
Publication year - 2019
Publication title -
clinical transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 76
eISSN - 1399-0012
pISSN - 0902-0063
DOI - 10.1111/ctr.13446
Subject(s) - medicine , lung cancer , lung , lung transplantation , adenocarcinoma , transplantation , stage (stratigraphy) , respiratory disease , cancer , pathology , biology , paleontology
Background The aim of our study was to describe the lung cancer characteristics in lung transplant recipients at our institution. Methods Between January 1, 1992, and August 15, 2017, 463 patients underwent lung transplantation. Results We found a total of 19 lung cancers (4.10%). Eight patients had lung cancer in the explanted lung, 8 in the native remaining lung, and 3 in the transplanted lung. Histopathological findings were: adenocarcinoma in 10, SCC in 8 patients, and 1 was undetermined. Among lung cancers in the explanted lungs, there were 6 stage I, 1 stage III, 1 stage IV. Among patients with a lung cancer in the remaining native lung, 3 had early stage disease and 5 had stage IV disease. Among lung cancers in the transplanted lung, there were: 1 stage I, 1 stage II and 1 stage IV. Overall median survival in lung transplant recipients without lung cancer was 8.77 ± 0.74 years compared to 6.19 ± 1.4 years in recipients with lung cancer. Conclusion Lung cancer following lung transplantation was uncommon. Early stage lung cancer discovered in the explanted lungs had no impact on survival. Lung cancer occurring in the transplanted or in the native remaining lung had a poor prognosis.