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Urinary angiotensinogen level is increased in renal transplant recipients with masked hypertension and is correlated with left ventricular mass index and albuminuria in these patients
Author(s) -
Tiryaki Ozlem,
Usalan Celalettin,
Kul Seval,
Tarakcioglu Mehmet,
Sucu Murat,
Yildiz Fahrettin,
Coban Sacit
Publication year - 2018
Publication title -
clinical transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 76
eISSN - 1399-0012
pISSN - 0902-0063
DOI - 10.1111/ctr.13375
Subject(s) - medicine , left ventricular hypertrophy , albuminuria , proteinuria , creatinine , urinary system , urology , cardiology , body mass index , endocrinology , renal function , kidney , blood pressure
Activation of the local renin‐angiotensin system ( RAS ) is an independent risk factor for the development of proteinuria and left ventricular hypertrophy ( LVH ) more commonly seen in masked hypertensives. It has been reported that urinary angiotensinogen ( UAGT ) level provides a specific index of the intrarenal RAS status. The aim of this study was to evaluate the association between UAGT and left ventricular mass index ( LVMI ) and urinary albumin‐creatinine ratio ( UACR ) in renal transplant recipients ( RTR s) with masked hypertension ( HT ). A total of 116 non‐diabetic‐treated hypertensive RTR s were included in this study. The patients were divided into two groups: masked hypertensives and controlled hypertensives. Forty‐two (36.2%) of RTR s had masked HT . Mean UACR and LVMI levels were higher in RTR s with masked HT than in RTR s with controlled HT ( P < 0.001). UAGT level was also higher in masked hypertensives compared to controlled hypertensives ( P < 0.001). Multivariable regression analysis showed that UAGT was positively correlated with UACR ( β = 0.024, P = 0.001) and LVMI ( β = 0.082, P = 0.001) in masked hypertensives. Consequently, masked HT was considerably frequent (36.2%) in treated hypertensive RTR s and high UAGT levels accompanied by high albuminuria and LVMI levels were seen in these patients. Overproduction of the UAGT may play a pivotal role in the development of LVH and proteinuria in masked hypertensives.