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Role of the oxidative stress index, myeloperoxidase, catalase activity for cardiac allograft vasculopathy in heart transplant recipients
Author(s) -
Kargin Ramazan,
Emiroglu Mehmet Yunus,
Evlice Mert,
Celik Mehmet,
Toprak Aybala Erek,
Avci Anil,
Ayturk Mehmet,
Kulahcioglu Seyhmus,
Bulut Mustafa,
Caliskan Mustafa
Publication year - 2018
Publication title -
clinical transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 76
eISSN - 1399-0012
pISSN - 0902-0063
DOI - 10.1111/ctr.13273
Subject(s) - medicine , myeloperoxidase , oxidative stress , catalase , gastroenterology , univariate analysis , antioxidant capacity , cardiac allograft vasculopathy , cardiology , heart transplantation , endocrinology , transplantation , inflammation , multivariate analysis
Background The aim of this study was to explore the role of oxidative stress index (OSI), myeloperoxidase (MPO), and catalase (CAT) activity in cardiac allograft vasculopathy (CAV) in heart transplant recipients (HTRs). Methods The study enrolled a median age of 41 ± 9 years 47 recipients. The HTx patients were divided into two groups based on the presence CAV as follows: CAV (+) and CAV (−) group. Also, CAV (+) group were divided into two groups as mild/moderate to severe CAV. The OSI, MPO, and CAT activity were analyzed in both groups. Results The mean total antioxidant capacity (0.79 ± 0.46 vs 1.03 ± 0.33 μmol H 2 O 2 equiv/L) P = .043 was significantly lower and OSI, MPO, CAT activity were significantly higher in CAV (+) group (63 ± 38 vs 20 ± 16 arbitrary unit, P = .001; 398 ± 242 vs 139 ± 112 μg/L, P = .001; 51 ± 42 vs 26 ± 23 pmol/mg protein, P = .013, respectively). Also, mean OSI (38 ± 41 vs 93 ± 75, P = .05) were significantly higher in severe CAV (+) group. Recipient age, male gender, and low density lipoprotein‐cholesterol were significantly higher in CAV (+) group. There was a moderate correlation between the CAV grade and OSI, MPO, and CAT levels in univariate analysis ( r = .560, P = .002; r = .643, P = .007; r = .681, P = .001, respectively). Conclusion An increase in the serum level of OSI, MPO, and CAT was associated with CAV in HTRs.