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The multidisciplinary support in preventing alcohol relapse after liver transplantation: A single‐center experience
Author(s) -
Attilia Maria Luisa,
Lattanzi Barbara,
Ledda Roberta,
Galli Anna Maria,
Farcomeni Alessio,
Rotondo Claudia,
Di Gregorio Vincenza,
Mennini Gianluca,
Poli Edoardo,
Attilia Fabio,
Ginanni Corradini Stefano,
Rossi Massimo,
Merli Manuela
Publication year - 2018
Publication title -
clinical transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 76
eISSN - 1399-0012
pISSN - 0902-0063
DOI - 10.1111/ctr.13243
Subject(s) - medicine , transplantation , alcoholic liver disease , liver transplantation , single center , psychosocial , alcohol , multivariate analysis , relapse prevention , gastroenterology , surgery , cirrhosis , psychiatry , biochemistry , chemistry
Background and aim Alcoholic liver disease ( ALD ) represents a frequent indication for liver transplantation ( LT ). Since 2004, we have adopted a program of multidisciplinary support( MS ) to assist patients undergoing LT for ALD . We aimed at analyzing the relapse rate and the risk factors for relapse. The relapse rate was also compared with that of a historical group of patients who underwent transplantation. Their survival rate was also analyzed. Patients and methods Consecutive patients with ALD transplanted from 2004 were included. The most important demographic, psychosocial, and clinical characteristics known to be associated with alcohol relapse were recorded. Results Sixty‐nine patients underwent MS : 8.7% presented alcohol relapse. At multivariate analysis female gender ( sHR 9.02, 95% CI 1.71‐47.56, P = .009), alcohol withdrawal syndrome ( sHR 5.89, 95% CI 1.42‐24.46, P = .015) and a shorter time of MS program before LT ( sHR 0.928 per month, 95% CI 0.870‐0.988, P = .021) were identified as independent risk factors for relapse. The rate of alcohol relapse was significantly lower than that of the historical group who did not undergo MS ( sHR 0.21, 95% CI : 0.06‐0.68; P = .009). Conclusion This study shows that a MS program may contribute to alcohol relapse prevention after LT in ALD patients. However, the relevance of this support needs to be confirmed by clinical trials.