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Cholinesterase levels predict exercise capacity in cardiac recipients early after transplantation
Author(s) -
Kitagaki Kazufumi,
Nakanishi Michio,
Ono Rei,
Yamamoto Kazuya,
Suzuki Yuji,
Fukui Noriyuki,
Yanagi Hidetoshi,
Konishi Harumi,
Yanase Masanobu,
Fukushima Norihide
Publication year - 2018
Publication title -
clinical transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 76
eISSN - 1399-0012
pISSN - 0902-0063
DOI - 10.1111/ctr.13170
Subject(s) - medicine , isometric exercise , cardiology , heart failure , cholinesterase , transplantation , physical therapy , endocrinology
Purpose Although cardiac rehabilitation is recommended for patients early after heart transplantation ( HT x), adequate exercise effect cannot always be obtained, partly because in patients with chronic heart failure, exercise capacity is reduced due to malnutrition while waiting for HT x. This study aimed to investigate the relationships between exercise capacity and clinical variables, including nutritional indicators, early after HT x. Patients and Methods Forty‐three HT x recipients were studied. The mean age at HT x was 38 ± 14 years, and 86% were male. We assessed the relationships between peak oxygen uptake ( VO 2 ) and clinical variables, including plasma B‐type natriuretic peptide ( BNP ), isometric knee extensor muscle strength ( KEMS ), and nutritional indicators within 1 week of their respective discharges. Results Peak VO 2 correlated positively with isometric KEMS ( r = .63, P < .0001) and negatively with BNP level ( r = −.37, P = .015). Of the nutritional indicators, only cholinesterase levels had a significant relationship with peak VO 2 ( r = .34, P = .028), whereas the Geriatric Nutritional Risk Index and the Controlling Nutritional Status scores did not. In multiple linear regression analysis, cholinesterase levels and isometric KEMS were independent predictors of peak VO 2 . Conclusion Cholinesterase levels predicted exercise capacity early after HT x.