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Outcome comparison of liver transplantation for hepatitis A‐related versus hepatitis B‐related acute liver failure in adult recipients
Author(s) -
Jung DongHwan,
Hwang Shin,
Lim YoungSuk,
Kim KiHun,
Ahn ChulSoo,
Moon DeokBog,
Ha TaeYong,
Song GiWon,
Park GilChun,
Lee SungGyu
Publication year - 2018
Publication title -
clinical transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 76
eISSN - 1399-0012
pISSN - 0902-0063
DOI - 10.1111/ctr.13140
Subject(s) - medicine , liver transplantation , gastroenterology , hepatitis a , hepatitis a virus , hepatitis b virus , hepatitis b , acute pancreatitis , transplantation , hepatitis , immunology , virus
Abstract Hepatitis A virus ( HAV ) can cause acute liver failure ( ALF ). This study compares outcomes between liver transplantation ( LT ) for HAV ‐related ALF ( HAV ‐ ALF ) and LT for hepatitis B virus ( HBV )‐related ALF ( HBV ‐ ALF ). Of 3616 adult LT s performed between January 2005 and December 2014, we performed LT for HAV ‐ ALF recipients (n = 29) and LT for HBV ‐ ALF recipients (n = 34). HAV ‐ ALF group included 18 males and 11 females with mean age of 33.1 years. Graft survival rates in HAV ‐ ALF and HBV ‐ ALF were 65.5% and 88.0% (1 year) and 65.5% and 84.0% (5 years) ( P = .048). Patient survival rates in HAV ‐ ALF and HBV ‐ ALF were 69.0% and 88.0% (1 year) and 69.0% and 84.0% (5 years) ( P = .09). Multivariate analyses demonstrated that acute pancreatitis and HAV recurrence were independent risk factors of graft and patient survival. Post‐transplant outcome was poorer in patients with HAV ‐ ALF than in those with HBV ‐ ALF . This weakens LT 's appropriateness in HAV ‐ ALF patients with pancreatitis. HAV recurrence after LT for HAV ‐ ALF is common and often fatal; thus, HAV recurrence should be monitored vigilantly, beginning early post‐transplant.