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Kidney transplantation from donors with rhabdomyolysis and acute renal failure
Author(s) -
Chen Chuanbao,
Zheng Yitao,
Zhou Jian,
Han Ming,
Wang Xiaoping,
Yuan Xiaopeng,
Wang Changxi,
He Xiaoshun
Publication year - 2017
Publication title -
clinical transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 76
eISSN - 1399-0012
pISSN - 0902-0063
DOI - 10.1111/ctr.13021
Subject(s) - medicine , rhabdomyolysis , contraindication , renal function , transplantation , kidney transplantation , urology , creatinine , renal replacement therapy , kidney , acute tubular necrosis , acute kidney injury , anuria , creatine kinase , surgery , tubulopathy , myoglobin , gastroenterology , pathology , alternative medicine , chemistry , organic chemistry
Rhabdomyolysis in deceased donors usually causes acute renal failure ( ARF ), which may be considered a contraindication for kidney transplantation. From January 2012 to December 2016, 30 kidneys from 15 deceased donors with severe rhabdomyolysis and ARF were accepted for transplantation at our center. The peak serum creatinine (SCr) kinase, myoglobin, and SCr of the these donors were 15 569±8597 U/L, 37 092±42 100 μg/L, and 422±167 μmol/L, respectively. Two donors received continuous renal replacement therapy due to anuria. Six kidneys exhibited a discolored appearance (from brown to glossy black) due to myoglobin casts. The kidney transplant results from the donors with rhabdomyolysis donors were compared with those of 90 renal grafts from standard criteria donors ( SCD ). The estimated glomerular filtration rate at 2 years was similar between kidney transplants from donors with rhabdomyolysis and SCD (70.3±14.6 mL/min/1.73 m 2 vs 72.3±15.1 mL/min/1.73 m 2 ). We conclude that excellent graft function can be achieved from kidneys donors with ARF caused by rhabdomyolysis.