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Nephrectomy‐induced reduced renal function and the health‐related quality of life of living kidney donors
Author(s) -
Han Xiao,
Lim Joel Yu Ming,
Raman Lata,
Tai Bee Choo,
Kaur Hersharan,
Goh Angeline Ting Hui,
Vathsala Anantharaman,
Tiong Ho Yee
Publication year - 2017
Publication title -
clinical transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 76
eISSN - 1399-0012
pISSN - 0902-0063
DOI - 10.1111/ctr.12910
Subject(s) - medicine , nephrectomy , renal function , proteinuria , kidney disease , kidney , quality of life (healthcare) , urology , diabetes mellitus , endocrinology , nursing
Objective To evaluate the health impact of nephrectomy on living kidney donors ( LKD s) by comparing the health‐related quality of life (HrQOL) scores measured by Short Form‐36 ( SF 36) between those with and without postdonation renal function impairment ( PRFI ). Methods Eighty‐two LKD s (47 females, mean age=50.2±11.2 years) were prospectively recruited to participate in a SF ‐36 Hr QOL survey. Chart review, individual baseline, and postoperative renal function ( eGFR ) was determined using the Modification of Diet in Renal Disease formula. PRFI was defined as eGFR <60 mL/min/1.73 m 2 or proteinuria. Mean SF ‐36 domain scores were compared between those with and without PRFI. Results After a median follow‐up of 5.7 years, the prevalence of postdonation comorbidities was 29.3% (n=24) PRFI , 25.6% (n=21) hypertension, 6.1% (n=5) diabetes, and 3.7% (n=3) heart disease, and no LKD s developed end‐stage renal disease. Mean eGFR before and after donor nephrectomy was 95.5±23.4 and 71.0±17.3 mL/min/1.73 m 2 ( P <.01). Mean SF ‐36 scores of LKD s were not significantly different between those with and without PRFI in all the domains (all P >.05). Similarly, the proportion of LKD s with PRFI did not differ significantly between the patients with SF ‐36 domain scores above and below the published reference values. Conclusion Nephrectomy‐induced PRFI may not have a significant impact on the Hr QOL of the LKD population with a low proportion of other major comorbidities such as diabetes and ischemic heart disease.