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Preliver transplant red cell distribution width predicts postliver transplant mortality
Author(s) -
Caire M. Thure,
Kumar Ambuj,
Stravitz R. Todd,
Kemmer Nyingi
Publication year - 2017
Publication title -
clinical transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 76
eISSN - 1399-0012
pISSN - 0902-0063
DOI - 10.1111/ctr.12908
Subject(s) - medicine , red blood cell distribution width , liver transplantation , receiver operating characteristic , retrospective cohort study , continuous variable , mann–whitney u test , gastroenterology , bilirubin , transplantation , surgery
Purpose Prognostication following liver transplantation is limited. Red cell distribution width ( RDW ) has been associated with morbidity and mortality in a variety of diseases. We hypothesize RDW is predictive of mortality postliver transplantation. Methods We performed a retrospective cohort study of all consecutive liver transplantation recipients at a tertiary care center from January 1, 2012 to December 31, 2012. The primary end point was association of RDW with one‐year mortality. Statistical analysis was performed using the Mann‐Whitney test, independent samples t test, and regression analysis. Discrimination was assessed by calculating area under receiver operating curves ( AUC ). A P ‐value <.05 was considered significant. Results RDW was positively associated with one‐year mortality ( P <.001). The mean difference for survivors compared to nonsurvivors was 3.9% (95% CI 1.9%‐5.9%). The AUC for RDW was 0.831 (95% CI 0.727‐0.935), compared to 0.723 (0.539‐0.908) for total bilirubin and 0.704 (0.479‐0.929) for the international normalized ratio. Conclusions To our knowledge, this is the first report of an association of RDW with post‐ LT mortality and the results show the predictive value of pre‐ LT RDW for one‐year mortality.