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BALF cytokines in different phenotypes of chronic lung allograft dysfunction in lung transplant patients
Author(s) -
Berastegui Cristina,
GómezOllés Susana,
SánchezVidaurre Sara,
Culebras Mario,
Monforte Victor,
LópezMeseguer Manuel,
Bravo Carlos,
Ramon MariaAntonia,
Romero Laura,
Sole Joan,
Cruz MariaJesus,
Román Antonio
Publication year - 2017
Publication title -
clinical transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 76
eISSN - 1399-0012
pISSN - 0902-0063
DOI - 10.1111/ctr.12898
Subject(s) - neutrophilia , medicine , bronchiolitis obliterans , bronchoalveolar lavage , immunology , lung transplantation , lung , tumor necrosis factor alpha , population , pathology , environmental health
The long‐term success of lung transplantation ( LT ) is limited by chronic lung allograft dysfunction ( CLAD ). Different phenotypes of CLAD have been described, such as bronchiolitis obliterans syndrome ( BOS ) and restrictive allograft syndrome ( RAS ). The purpose of this study was to investigate the levels of cytokines and chemokines in bronchoalveolar lavage fluid ( BALF ) as markers of these CLAD phenotypes. BALF was collected from 51 recipients who underwent (bilateral and unilateral) LT . The study population was divided into three groups: stable ( ST ), BOS , and RAS . Levels of interleukin ( IL )‐4, IL ‐5, IL ‐6, IL ‐10, IL ‐13, tumor necrosis factor alpha ( TNF ‐α), interferon‐gamma ( IFN ‐γ), and granulocyte‐macrophage colony‐stimulating factor ( GM ‐ CSF ) were measured using the multiplex technology. BALF neutrophilia medians were higher in BOS (38%) and RAS (30%) than in ST (8%) ( P =.008; P =.012). Regarding BALF cytokines, BOS and RAS patients showed higher levels of INF ‐ γ than ST ( P =.02; P =.008). Only IL ‐5 presented significant differences between BOS and RAS ( P =.001). BALF neutrophilia is as a marker for both CLAD phenotypes, BOS and RAS , and IL ‐5 seems to be a potential biomarker for the RAS phenotype.