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Determinants of pre‐transplantation pectoralis muscle area ( PMA ) and post‐transplantation change in PMA in lung transplant recipients
Author(s) -
Hoang Van,
Li Gloria W.,
Kao Christina C.,
Dronavalli Goutham,
Parulekar Amit D.
Publication year - 2017
Publication title -
clinical transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 76
eISSN - 1399-0012
pISSN - 0902-0063
DOI - 10.1111/ctr.12897
Subject(s) - medicine , transplantation , lung transplantation , quartile , copd , interstitial lung disease , pectoralis major muscle , lung , surgery , gastroenterology , confidence interval
Background This study aimed to determine predictors of pectoralis muscle area ( PMA ) and assess change in PMA following lung transplantation and its relationship to outcomes. Methods A retrospective review of 88 lung transplant recipients at a single center was performed. PMA was determined on a single axial slice from chest computerized tomography. Pectoralis muscle index ( PMI ) was calculated from the PMA divided by the height squared. Results PMI decreased post‐transplantation (8.1±2.8 cm 2 /m 2 pre‐transplantation, 7.5±2.9 cm 2 /m 2 at 6 months, and 7.6±2.7 cm 2 /m 2 at 12 months, P <.05). Chronic obstructive pulmonary disease ( COPD ) and interstitial lung disease ( ILD ) were predictors of pre‐transplant PMI (β=−2.3, P =.001 for COPD ; β=2.1, P <.001 for ILD ) and percent change in PMI at 12 months post‐transplantation relative to baseline (β=19.2, P =.04 for COPD ; β=−20.1, P =.01 for ILD ). Patients in the highest quartile for PMI change at 12 months had fewer ventilator days compared with patients in the other quartiles ( P =.03). Conclusions Underlying diagnosis was a significant predictor of both pre‐transplantation PMI and change in PMI post‐transplantation. Further studies of PMI are needed to determine its clinical utility in predicting outcomes following lung transplantation.