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Cost and clinical outcome of islet transplantation in Norway 2010‐2015
Author(s) -
Schive Simen W.,
Foss Aksel,
Sahraoui Afaf,
KlosterJensen Kristine,
Hafsahl Geir,
Kvalheim Gunnar,
Lundgren Torbjørn,
ZurMühlen Bengt,
Felldin Marie,
Rafael Ehab,
Lempinen Marko,
Korsgren Olle,
Jenssen Trond G.,
Mishra Vinod,
Scholz Hanne
Publication year - 2017
Publication title -
clinical transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 76
eISSN - 1399-0012
pISSN - 0902-0063
DOI - 10.1111/ctr.12871
Subject(s) - medicine , transplantation , outcome (game theory) , islet , intensive care medicine , surgery , diabetes mellitus , endocrinology , mathematics , mathematical economics
Islet transplantation is a minimally invasive β‐cell replacement strategy. Islet transplantation is a reimbursed treatment in Norway. Here, we summarize the cost and clinical outcome of 31 islet transplantations performed at Oslo University Hospital ( OUS ) from January 2010 to June 2015. Patients were retrospectively divided into three groups. Thirteen patients received either one or two islet transplantation alone ( ITA ), while five patients received islet transplantation after previous solid organ transplantation. For the group receiving 2 ITA , Kaplan‐Meier estimates show an insulin independence of 20% more than 4 years after their last transplantation. An estimated 70% maintain at least partial graft function, defined as fasting C‐peptide >0.1 nmol L −1 , and 47% maintain a HbA1c below 6.5% or 2 percent points lower than before ITA . For all groups combined, we estimate that 44% of the patients have a 50% reduction in insulin requirement 4 years after the initial islet transplantation. The average cost for an islet transplantation procedure was 347 297±60 588 NOK , or 35 424±6182 EUR , of which isolation expenses represent 34%. We hereby add to the common pool of growing experience with islet transplantation and also describe the cost of the treatment at our center.