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Acute cellular rejection and HLA mismatch in heart transplantation: insights from a developing country
Author(s) -
Schtruk Lígia Beatriz Chaves Espinoso,
Guimarães Tereza Cristina Fellipe,
Pôrto Luis Cristóvão,
Kuschnir Maria Cristina Caetano,
Colafranceschi Alexandre Siciliano,
Filho Paulo Moreira da Silva,
De Lorenzo Andrea
Publication year - 2016
Publication title -
clinical transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 76
eISSN - 1399-0012
pISSN - 0902-0063
DOI - 10.1111/ctr.12801
Subject(s) - medicine , human leukocyte antigen , heart transplantation , incidence (geometry) , endomyocardial biopsy , transplantation , typing , immunology , intensive care medicine , biopsy , cardiology , antigen , physics , biology , optics , genetics
The notable evolution of heart transplant ( HTX ) has paralleled the capacity of diagnosing rejection and, consequently, initiating timely treatment. Acute cellular rejection, diagnosed by endomyocardial biopsy, is the most frequent in the first 6 months after HTX . HLA matching is not routinely performed in HTX due to the absence of consensus regarding its usefulness. However, the use of HLA typing might be underscored if it could predict an increased risk of rejection. Therefore, the aim of this study was to evaluate, at a public cardiology center in Brazil, the association between HLA mismatches and the incidence of acute cellular rejection in the first 6 months after HTX . Data were obtained from hospital records and from the National Transplant System. Overall, there was no association between the number of HLA mismatches and the frequency of acute cellular rejection, but there was a tendency toward a higher incidence of rejection with HLA ‐ DR incompatibility.