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Cytomegalovirus‐negative kidney transplant recipients are at an increased risk for malignancy after kidney transplantation
Author(s) -
RozenZvi Benaya,
Lichtenberg Shelly,
Green Hefziba,
Cohen Ori,
Chagnac Avry,
Mor Eytan,
Rahamimov Ruth
Publication year - 2016
Publication title -
clinical transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 76
eISSN - 1399-0012
pISSN - 0902-0063
DOI - 10.1111/ctr.12775
Subject(s) - medicine , malignancy , hazard ratio , cytomegalovirus , kidney transplantation , transplantation , gastroenterology , serology , univariate analysis , confidence interval , cancer , proportional hazards model , human cytomegalovirus , immunology , multivariate analysis , herpesviridae , viral disease , virus , antibody
Background The effect of cytomegalovirus ( CMV ) serology status on malignancy risk in kidney transplanted patients is not clear yet. Methods In a nested case–control study, CMV serology status was compared between patients with a malignancy and 2:1 matched control patients without a malignancy. In a cohort study, the hazard of malignancy was compared between patients that were CMV ‐negative but had a CMV ‐positive donor and other patients, using Cox analysis. Results Fifty‐two of 599 patients transplanted in our center between 2001 and 2014 developed a malignancy. Nine (17.3%) of the 52 patients that developed cancer were CMV ‐negative but had a‐ CMV ‐positive donor compared with 6 (5.8%) of the 104 matched control patients (odd ratio 3.42, 95% confidence interval [ CI ] 1.15–10.2, P =.021). By univariate Cox model, there was a trend toward increased cancer risk in CMV ‐negative patients with a positive donor (hazard ratio [ HR ] 1.95, 95% CI 0.95–4.0, P =.07), but after adjusting for multiple covariates, CMV ‐negative status was significantly associated with increased risk of cancer ( HR 2.55, 95% CI 1.23–5.26; P =.012). Conclusions CMV‐negative patients that had a CMV ‐positive donor were found to have a higher risk of malignancy after kidney transplantation.