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Effect of prior hepatitis B virus exposure on long‐term risk of liver‐related events after liver transplantation
Author(s) -
Chen PoHung,
Limketkai Berkeley N.,
Trilianos Panagiotis,
PirtiniCetingul Muge,
Woreta Tinsay A.,
Kim Brian,
Gulsen Murat T.,
Segev Dorry L.,
Cameron Andrew M.,
Gurakar Ahmet
Publication year - 2016
Publication title -
clinical transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 76
eISSN - 1399-0012
pISSN - 0902-0063
DOI - 10.1111/ctr.12723
Subject(s) - medicine , liver transplantation , hazard ratio , hepatitis b virus , cirrhosis , gastroenterology , hepatitis b , hepatitis c , transplantation , hepatitis , confidence interval , immunology , virus
Objective To characterize the risk of liver‐related events and death in hepatitis B virus ( HBV )‐exposed liver transplantation ( LT ) recipients. Methods Retrospective review was performed in all adults who underwent LT between January 1995 through December 2010 at the Johns Hopkins Hospital. Recipients with graft failure or death within 14 d of LT or missing HBV status were excluded, leaving 575 individuals for analysis. Patients were classified according to HBV exposure status: Unexposed, Resolved HBV , Chronic HBV , or hepatitis B core antibody (anti‐ HB c) seropositive liver donor. Results Compared with HBV ‐unexposed patients, the relative hazard of combined liver‐related events (rejection, cirrhosis, re‐transplantation) and death after LT was not increased in patients with a baseline history of resolved HBV infection or chronic hepatitis B. Using anti‐ HB c seropositive donors also did not increase the risk of liver‐related events, death, or composite events (all p ≥ 0.05). However, hepatitis C was associated with liver‐related events [adjusted hazard ratio ( aHR ), 1.59; 95% confidence interval ( CI ), 1.00–2.52], and blacks had a higher risk of death ( aHR , 1.50; 95% CI , 1.01–2.22). Conclusion LT of patients with prior HBV exposure or use of anti‐ HB c seropositive donors is not associated with increased risk of liver‐related events or death.