Premium
Serial perfusion in native lungs in patients with idiopathic pulmonary fibrosis and other interstitial lung diseases after single lung transplantation
Author(s) -
Sokai Akihiko,
Handa Tomohiro,
Chen Fengshi,
Tanizawa Kiminobu,
Aoyama Akihiro,
Kubo Takeshi,
Ikezoe Kohei,
Nakatsuka Yoshinari,
Oguma Tsuyoshi,
Hirai Toyohiro,
Nagai Sonoko,
Chin Kazuo,
Date Hiroshi,
Mishima Michiaki
Publication year - 2016
Publication title -
clinical transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 76
eISSN - 1399-0012
pISSN - 0902-0063
DOI - 10.1111/ctr.12701
Subject(s) - medicine , lung transplantation , lung , idiopathic pulmonary fibrosis , pulmonary fibrosis , perfusion , cystic fibrosis , transplantation , pathology , fibrosis , cardiology
Background Lung perfusions after single lung transplantation ( SLT ) have not been fully clarified in patients with interstitial lung disease ( ILD ). The present study aimed to investigate temporal changes in native lung perfusion and their associated clinical factors in patients with ILD who have undergone SLT . Methods Eleven patients were enrolled. Perfusion scintigraphy was serially performed up to 12 months after SLT . Correlations between the post‐operative perfusion ratio in the native lung and clinical parameters, including pre‐operative perfusion ratio and computed tomography ( CT ) volumetric parameters, were evaluated. Results On average, the perfusion ratio of the native lung was maintained at approximately 30% until 12 months after SLT . However, the ratio declined more significantly in idiopathic pulmonary fibrosis ( IPF ) than in other ILD s (p = 0.014). The perfusion ratio before SLT was significantly correlated with that at three months after SLT (ρ = 0.64, p = 0.048). The temporal change of the perfusion ratio in the native lung did not correlate with those of the CT parameters. Conclusion The pre‐operative perfusion ratio may predict the post‐operative perfusion ratio of the native lung shortly after SLT in ILD . Perfusion of the native lung may decline faster in IPF compared with other ILD s.