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Clinical relevance of preformed IgG and IgM antibodies against donor endothelial progenitor cells in recipients of living donor kidney grafts
Author(s) -
Daniel Volker,
Sadeghi Mahmoud,
Suesal Caner,
Scherer Sabine,
Tran Hien,
Gombos Petra,
Trojan Karina,
Morath Christian,
Opelz Gerhard
Publication year - 2016
Publication title -
clinical transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 76
eISSN - 1399-0012
pISSN - 0902-0063
DOI - 10.1111/ctr.12665
Subject(s) - medicine , antibody , immunology , transplantation , creatinine , donor specific antibodies , immunoglobulin m , clinical significance , kidney transplantation , kidney , progenitor cell , immunoglobulin g , stem cell , biology , genetics
Background Literature reports suggest that non‐ HLA ‐antibodies against human endothelial progenitor cells ( EPC ) can be detected in pre‐transplant recipient serum and that EPC antibodies can have a deleterious influence on the graft. Methods We investigated 71 renal transplant recipients from living donors for a possible influence of pre‐transplant donor‐specific IgG and/or IgM recipient antibodies against EPC of the donor using the flow cytometric XM ‐ ONE cross‐match. Results Eight of the 71 patients developed acute biopsy‐proven rejection. Two of these patients showed IgM antibodies against EPC prior to transplantation while the other six patients had neither IgG nor IgM EPC antibodies. Conversely, pre‐transplant IgG or IgM antibodies against EPC were detected in 19 patients without acute rejection (3 × both IgG and IgM, 1 × IgG and 15 × IgM). The remaining 44 patients had neither EPC antibodies nor experienced rejection. Comparing serum creatinine levels at one month and one yr post‐transplant within and among the three patient groups revealed that serum creatinine levels were similar in patients with or without EPC antibodies (p > 0.05). Conclusion In this series of 71 recipients with living donor kidneys, pre‐transplant EPC antibodies detected with the XM ‐ ONE test kit were neither associated with acute rejection nor with graft function at one month or one yr.