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Impact of different immunosuppressive regimens on the health‐related quality of life following orthotopic liver transplantation
Author(s) -
Benzing Christian,
Krezdorn Nicco,
Förster Julia,
Hinz Andreas,
Atanasov Georgi,
Wiltberger Georg,
Morgül Mehmet H.,
Lange Undine G.,
Schmelzle Moritz,
Hau HansMichael,
Bartels Michael
Publication year - 2015
Publication title -
clinical transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 76
eISSN - 1399-0012
pISSN - 0902-0063
DOI - 10.1111/ctr.12631
Subject(s) - medicine , immunosuppression , quality of life (healthcare) , liver transplantation , discovery and development of mtor inhibitors , sirolimus , azathioprine , prednisolone , transplantation , pi3k/akt/mtor pathway , gastroenterology , apoptosis , disease , nursing , biochemistry , chemistry
Background The influence of immunosuppression on the recipients’ quality of life (QoL) is of major importance after OLT and has not yet been evaluated. Methods The impact of different immunosuppression regimens after OLT was evaluated in 275 patients using the Short Form 36 ( SF ‐36) survey. The following immunosuppressive strategies were compared: (a) CNI , (b) mTOR inhibitors, and (c) mTOR combined with CNI . All regimens were prescribed alone (mono) or in combination (+) with prednisolone and/or mycophenolate mofetil ( MMF ). Results Highest scores were evident in patients in the mTOR + group. There were significantly higher values for general health perceptions ( GH , p = 0.049), vitality ( VIT , p = 0.020), and physical component summary ( PCS , p = 0.041) when compared to CNI mono and for GH (p = 0.042) and VIT (p = 0.043), when compared to mTOR mono. Early conversion to mTOR inhibitors (two months after OLT ), with a statistically significant improvement for the dimension role‐emotional ( RE , p = 0.027). Discussion mTOR inhibitor‐based regimens appear to have beneficial effects on QoL after OLT , especially after an early conversion.