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A prospective analysis of factors associated with decreased physical activity in patients with cirrhosis undergoing transplant evaluation
Author(s) -
Dela Cruz Anna Christina,
Vilchez Valery,
Kim Sooyeon,
Barnes Benjamin,
Ravinuthala Abhishek,
Zanni Anthony,
Galuppo Roberto,
Sourianarayanane Achuthan,
Patel Trushar,
Maynard Erin,
Shah Malay B.,
Daily Michael F.,
Uhl Timothy,
Esser Karyn,
Gedaly Roberto
Publication year - 2015
Publication title -
clinical transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 76
eISSN - 1399-0012
pISSN - 0902-0063
DOI - 10.1111/ctr.12602
Subject(s) - medicine , grip strength , cirrhosis , liver transplantation , prospective cohort study , gastroenterology , liver disease , alcoholic liver disease , chronic liver disease , hand strength , steatohepatitis , fatty liver , model for end stage liver disease , transplantation , surgery , disease
Background Physical activity (PA) has been associated with improved recovery time after transplantation. Handgrip strength has been related to post‐transplant outcomes. Aim To evaluate predictors of PA and grip strength in patients with cirrhosis undergoing liver transplant evaluation. Methods Single‐center, prospective analysis. Results One hundred patients were evaluated (54% male, mean age 53 ± 9). Common etiologies of liver disease were non‐alcoholic steatohepatitis (27%), hepatitis C (22%) and alcoholic liver disease (21%). Mean model of end‐stage liver disease ( MELD ) score was 13.5. Forty‐one percent had a history of smoking. Ninety‐three patients completed the International Physical Activity Questionnaire ( IPAQ ). The median total PA score was 33 metabolic equivalent ( MET )‐min/wk. The mean total grip strength was 62.1 ± 22 lb. Total grip strength was found to be an independent predictor of low–moderate PA ( OR 4.7, 95% CI 1.4–16.2, p = 0.038), and smoking was the only significant factor associated with reduced grip strength ( OR 3.4, 95% CI 1.4–8, p = 0.005). Conclusions Patients with end‐stage liver disease undergoing liver transplant evaluation have reduced total PA by IPAQ. Total grip strength was found to be a significant predictor of low–moderate PA in patients with cirrhosis. Smoking is a risk factor for reduced grip strength, an important indicator of muscle wasting in cirrhotics.